Publication

2020


1. Y. Wang, M. Gao, F. Zhu, X. Li, Y. Yang, Q. Yan, L. Jia, L. Xie*, Z. Chen*. METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice. Nat Commun 2020. PubMed
2. J. Li, X. Pan, Gu. Pan, Z. Song, Y. He, S. Zhang, X. Ye, X. Yang, E. Xie, X. Wang, X. Mai, X. Yin, B. Tang, X. Shu, P. Chen, X. Dai, Y. Tian, L. Yao, M. Han, G. Xu, H. Zhang, J. Sun, H. Chen, F. Wang*, J. Min* and L. Xie*. Transferrin Receptor 1 Regulates Thermogenic Capacity and Cell Fate in Brown/Beige Adipocytes. Advanced Science, 2020. PubMed
3. Z. Liu, C. Cai, J. Du, B. Liu, L. Cui, X. Fan, Q. Wu, J. Fang*, L. Xie*. TCMIO: A Comprehensive Database of Traditional Chinese Medicine on Immuno-Oncology. Front. Pharmacol. 2020. PubMed
4. B. Liu, X. Pan, Z. Liu, M. Han, G. Xu, X. Dai, W. Wang, H. Zhang, L. Xie*. Fecal microbiota as a non-invasive biomarker to predict the tissue iron accumulation in intestine epithelial cells and liver. FASEB J. 2020 PubMed
5. Y. Wu, Y.g Gong, Y. Luan, Y. Li, J. Liu, Z. Yue, B. Yuan, Ji. Sun, C. Xie, L. Li, J. Zhen, X. Jin, Y. Zheng, X. Wang, L. Xie*, W. Wang*. BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer's disease. FASEB J. 2020 PubMed
6. G. Pan, B. Liu, S. Li, M. Han, L. Gao, G. Xu, Q. Du*, L. Xie*, Kuijieling, a Chinese medicine alleviates DSS-induced colitis in C57BL/6Jmouse by improving the diversity and function of gut microbiota, FEMS Microbiol. Lett. 2020 PubMed
7. X. Mai, M. Han, Y. Yin, G. Xu, J. Sun, H. Chen, L. Xie*, The metabolic function of the metal transporter SLC39A14. Chinese Science Bulletin(科学通报) 2020. Link
8. J. Li, X. Pan, Gu. Pan, Z. Song, Y. He, S. Zhang, X. Ye, X. Yang, E. Xie, X. Wang, X. Mai, X. Yin, B. Tang, X. Shu, P. Chen, X. Dai, Y. Tian, L. Yao, M. Han, G. Xu, H. Zhang, J. Sun, H. Chen, F. Wang*, J. Min* and L. Xie*. Transferrin Receptor 1 Regulates Thermogenic Capacity and Cell Fate in Brown/Beige Adipocytes. Frontispiece of Advanced Science, 2020. Link
9. Y. Tian, X. Mai, M. Han, K. Ma, Y. Yin, G. Xu, R. Wang, J. Sun, H. Chen, L. Xie*, Research Advances in Intestinal Flora Regulating the Occurrence and Development of Metabolic Diseases. Chinese Science Bulletin(科学通报) 2020. Link
10. B. Zhou, L. Jia, Z. Zhang, L. Xiang, Y. Yuan, P. Zheng, B. Liu, X. Ren, H. Bian, L. Xie, Y. Li, J. Lu, H. Zhang, Y. Lu, The Nuclear Orphan Receptor NR2F6 Promotes Hepatic Steatosis through Upregulation of Fatty Acid Transporter CD36. Advanced Science 2020. Link
11. Liu, Z.; Huang, D.; Zheng, S.; Song, Y.; Liu, B.; Sun, J.; Niu, Z.; Gu, Q.*; Xu, J.*; Xie, L.* Deep Learning Enables Discovery of Highly Potent Anti-Osteoporosis Natural Products. Eur. J. Med. Chem. 2020, 112982. PubMed
12. W. Shi, L Shen, W. Zou, J. Wang, J. Yang, Y. Wang, B. Liu, L. Xie, J. Zhu, Z. Zhang The Gut Microbiome Is Associated With Therapeutic Responses and Toxicities of Neoadjuvant Chemoradiotherapy in Rectal Cancer Patients—A Pilot Study. Front. Cell. Infect. Microbiol.2020, 10:562463. PubMed
13. B. Zhou, L. Jia, Z. Zhang, L. Xiang, Y. Yuan, P. Zheng, B. Liu, X. Ren, H. Bian, L. Xie, Y. Li, J. Lu, H. Zhang, Y. Lu. The Nuclear Orphan Receptor NR2F6 Promotes Hepatic Steatosis through Upregulation of Fatty Acid Transporter CD36. Adv Sci. 2020 Sep 21;7(21):2002273. PubMed

2019

1. H. Li, B. Liu, J. Song, Z. An, X. Zeng, J. Li, J. Jiang, L. Xie, W. Wu. Characteristics of Gut Microbiota in Patients with Hypertension and/or Hyperlipidemia: A Cross-Sectional Study on Rural Residents in Xinxiang County, Henan Province. Microorganisms, 2019 Sep 26;7(10). pii: E399.
2. Z. Liu, D. Ji, J. Fang, Y. Yin, G. Xu, L. Xie. DeepScreening: a deep learning-based screening web server for accelerating drug discovery. Database (Oxford). 2019 Jan 1;2019. pii: baz104.
3. S. Chen, H. Ding, X. Yao, L. Xie. Isolation and culture of single myofiber and immunostaining of satellite cells from adult C57BL/6J mice. Bio-protocol 9(14): e3313
4. B. Liu, W. Lin, S. Chen, T. Xiang, Y. Yang, Y. Yin, G. Xu, Z. Liu, L. Liu, J. Pan, L. Xie. Gut microbiota as a subjective measurement for auxiliary of insomnia disorder. Front. Microbiol. 10:1770. doi: 10.3389/fmicb.2019.01770
5. B. Liu, X. Pan, L. Yao, S. Chen, Z. Liu, M. Han, Y. Yin, G. Xu, D. Wan, X. Dai, J. Sun, J. Pan, H. Zhang, W. Wang, L., L. Xie. Fecal microbiota as a non-invasive biomarker to predict the tissue iron accumulation in intestine epithelial cells and liver. bioRxiv.2019. Jan 2019:612168.
6. S. Herrlinger, Q. Shao, M, Yang, Q. Chang, Y, Liu, X. Pan, H. Yin, L. Xie, J. Chen. Lin28-mediated promotion of protein synthesis is critical for neural progenitor cell maintenance and brain development in mice. Development, 2019,146 (10), dev173765.
7. X. Pan, B. Liu, S. Chen, H. Ding, X. Yao, Y. Cheng, D. Xu, Y. Yin, X. Dai, J. Sun, G. Xu, J. Pan, L. Xiao, L. Xie. Nr4a1 as a myogenic factor is upregulated in satellite cells/myoblast under proliferation and differentiation state. BBRC, 2019 Jun 4;513(3):573-581
8. X. Yao, T. Yu, F. Xi, Y. XU, L. Ma, X. Pan, S. Chen, M. Han, Y. Yin, X. Dai, G. Xu, H. Zhang, G. Yang, L. Xie. BAMBI shuttling between cyto and membrane is required for skeletal muscle development and regeneration. BBRC, 2019 Jan 29; 509(1): 125-132
9. T. Zeng, Z. Liu, H. Liu, W. He, X. Tang, L. Xie, R. Wu. Exploring chemical and biological space of terpenoids. J Chem Inf Model. 2019, 59, 9,3667-3678.
10. W. Li, Y. Li, Y. Hu, X. Mo, G. Xu, L. Xie, A. Li. GroEL, a novel vaccine candidate of piscine Streptococcus agalactiae identified by immunoproteome. Fish Shellfish Immuno. 2019. 84, 377-383.

2018

1. W. Li, X. Pan, W. Chen, Y. Yin, J. Chen, G. Xu, L. Xie. Serum biochemistry, histology and transcriptomic profile analysis reflect liver inflammation and damage following dietary histamine supplementation in yellow catfish (Pelteobagrus fulvidraco). Fish Shellfish Immuno. 2018 Jun; 77:83-90
2. G. Chen, B. Huang, S. Fu, B. Li, X. Ran, D. He, L. Jiang, Y. Li, B. Liu, L. Xie, J. Liu, W. Wang. G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis. Front Immunol. 2018 Sep 13;9:2079
3. X. Tong, Q. Zhang, L. Wang, Y. Ji, L. Zhang, L. Xie, W. Chen, H. Zhang. RNF186 impairs insulin sensitivity by inducing ER stress in mouse primary hepatocytes. Cell Signal. 2018 Dec;52:155-162
4. L. Xie, A. Yin, A.S. Nichenko, A.M. Beedle, J.A. Call, H.Yin, Transient HIF2α Inhibition Accelerates Muscle Regeneration by Promoting Satellite Cell Proliferation. J Clin Invest. 2018 Jun 1;128(6):2339-2355.
5. X. Zhu, Q. Kong, L. Xie, Z. Chen, H. Li, Z. Zhu, Y. Huang, F. Lan, H. Luo, J. Zhan, H. Ding, J. Lei, Q. Xiao, W. Fu, W. Fan, J. Zhang, H. Luo. The single-nucleotide polymorphisms in CHD5 affect the prognosis of patients with hepatocellular carcinoma. Oncotarget. 2018 Mar 2; 9 (17):13222-13230.
6. X. Li, L. Jia, X. Chen, Y. Dong, X. Ren, Y. Dong, Y. Chen, L. Xie, M. Liu, C. Shiota, G.K. Gittes, L. Rui, Z. Chen. Islet α-cell inflammation induced by NF-kB Inducing kinase (NIK) leads to hypoglycemia, pancreatitis, growth retardation and postnatal death in mice. Theranostics. 2018 Nov 13;8(21):5960-5971.
7. Y. Long, S. Li, J. Qin, L. Xie, L. Gan, F. Jie, Y. Wu, Y. Li, Q. Du.Kuijieling regulates the differentiation of Treg and Th17 cells to ameliorate experimental colitis in rats. Biomed Pharmacother. 2018 Jun 15;105:781-788.

2017

1. L. Wang, X. Tong, F. Gu, L. Zhang, W. Chen, X. Cheng, L. Xie, Y., Chang, and H. Zhang, The KLF14 Transcription Factor Regulates Hepatic Gluconeogenesis in Mice. Journal of Biological Chemistry. 2017 Dec 29; 292 (52):21631–42.
2. C. Cao, T. Zhang, D. Zhang, L. Xie, X. Zou, L. Lei, D. Wu, L. Liu, The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma., Oncogene 36; 1112-1122 (2017).

2016

1. W. Qin, X. Li, L. Xie, S. Li, J. Liu, L. Jia, X. Dong, X. Ren, J. Xiao, C. Yang, Y. Zhou, Z. Chen, A long non-coding RNA, APOA4 -AS, regulates APOA4 expression depending on HuR in mice, Nucleic Acids Res. 44 (2016) 6423–6433.
2. X. Xue, S.K. Ramakrishnan, K. Weisz, D. Triner, L. Xie, D. Attili, A. Pant, B. Győrffy, M. Zhan, C. Carter-Su, K.M. Hardiman, T.D. Wang, M.K. Dame, J. Varani, D. Brenner, E.R. Fearon, Y.M. Shah, Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis, Cell Metab. 24 (2016) 447–461.

2015

1. C. Cao, J. Sun, D. Zhang, X. Guo, L. Xie, X. Li, D. Wu, L. Liu, The Long Intergenic Noncoding RNA UFC1, a Target of MicroRNA 34a, Interacts With the mRNA Stabilizing Protein HuR to Increase Levels of β-Catenin in HCC Cells, Gastroenterology. 2015 Feb; 148 (2):415–26.e18.
2. N. Das, L. Xie, S.K. Ramakrishnan, A. Campbell, S. Rivella, Y.M. Shah, Intestine-specific Disruption of Hypoxia-inducible Factor (HIF)-2α Improves Anemia in Sickle Cell Disease, J. Biol. Chem. 290 (2015) 23523–23527.
3. L. Gan, L. Xie, F. Zuo, Z. Xiang, N. He, Transcriptomic analysis of Rongchang pig brains and livers, Gene. 560 (2015) 96–106.

2014

1. L. Xie, X. Xue, M. Taylor, S.K. Ramakrishnan, K. Nagaoka, C. Hao, F.J. Gonzalez, Y.M. Shah, Hypoxia-Inducible Factor/MAZ-Dependent Induction of Caveolin-1 Regulates Colon Permeability through Suppression of Occludin, Leading to Hypoxia-Induced Inflammation, Mol. Cell. Biol. 2014 Aug;34 (16) 3013–23.
2. Y.M. Shah, L. Xie, Hypoxia-Inducible Factors Link Iron Homeostasis and Erythropoiesis, Gastroenterology. 2014 Mar; 146(3):630–642.
3. H. Zhang, Q. Chen, T. Jiao, A. Cui, X. Sun, W. Fang, L. Xie, Y. Liu, F. Fang, Y. Chang, Involvement of KLF11 in Hepatic Glucose Metabolism in Mice via Suppressing of PEPCK-C Expression, PLoS One. 2014; 9 (2): e89552.

2013

1. L. Xie, J.F. Collins, Copper stabilizes the Menkes copper-transporting ATPase (Atp7a) protein expressed in rat intestinal epithelial cells, AJP Cell Physiol. 2013 Feb 1; 304 (3): C257–62.
2. L. Xie, J.F. Collins, Transcription Factors Sp1 and HIF2α Mediate Induction of the Copper-transporting ATPase (Atp7a) Gene in Intestinal Epithelial Cells during Hypoxia, J. Biol. Chem. 2013 Aug 16; 288 (33) :23943–52.
3. E.R. Anderson, M. Taylor, X. Xue, S.K. Ramakrishnan, A. Martin, L. Xie, B.X. Bredell, S. Gardenghi, S. Rivella, Y.M. Shah, Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia, Proc. Natl. Acad. Sci. 2013 Dec 10; 110 (50) E4922–E4930.

2011

1. L. Xie, J.F. Collins, Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2α) in intestinal epithelial cells, AJP Cell Physiol. 300 (2011) C1298–C1305.

PubMed

https://pubmed.ncbi.nlm.nih.gov/?term=Liwei+Xie&sort=date

Chinese Patent
1. 发明名称:一种基于肠道菌群预测组织微量元素含量的预测方法和预测模型
    专利申请号:201910309446.5
    受理日期:2019年04月17日
    申请国家:中国
2. 发明名称:一种具有降血糖功效的益生菌制剂的功能性食品.专利申请号
    201910315091.0
    受理日期:2019年04月19日
    申请国家:中国
3. 发明名称:基于分子指纹和深度学习的高通量药物虚拟筛选系统
    专利申请号:201910234195.9
    受理日期:2019年03月26日
    申请国家:中国
4. 发明名称:生物碱在制备破骨细胞分化抑制剂中的应用
    专利申请号:202010537725X
    受理日期:2019年06月12日
    申请国家:中国
5. 发明名称:香草木宁碱在制备破骨细胞分化抑制剂中的应用
    专利申请号:2020105363420
    受理日期:2019年06月12日
    申请国家:中国
6. 发明名称:孕甾烷衍生物在制备破骨细胞分化抑制剂的应用
    专利申请号:2020105119972
    受理日期:2019年06月08日
    申请国家:中国

International Patent
1. 发明名称:基于分子指纹和深度学习的高通量药物虚拟筛选系统
    申请专利号:PCTCN2020072584
    受理日期:2020年1月17日
    申请国家:美国
2. 发明名称:Compositions and methods of modulating HIF-2α; to improve muscle generation and repair
    专利申请号:NO62/588,786
    受理日期:2017年11月20日
    申请国家:USA